Radar signal categorization using a neural network

Neural networks were used to analyze a complex simulated radar environment which contains noisy radar pulses generated by many different emitters. The neural network used is an energy minimizing network (the BSB model) which forms energy minima - attractors in the network dynamical system - based on learned input data. The system first determines how many emitters are present (the deinterleaving problem). Pulses from individual simulated emitters give rise to separate stable attractors in the network. Once individual emitters are characterized, it is possible to make tentative identifications of them based on their observed parameters. As a test of this idea, a neural network was used to form a small data base that potentially could make emitter identifications

In situ anticaries efficacy of dentifrices with different formulations – A pooled analysis of results from three randomized clinical trials

Objectives Data generated from three similar in situ caries crossover studies presented the opportunity to conduct a pooled analysis to investigate how dentifrice formulations with different fluoride salts and combinations at concentrations of 1400–1450 ppm F, different abrasive systems and in some cases, carbomer (Carb), affect enamel caries lesion remineralization and fluoridation. Methods Subjects continuously wore modified partial dentures holding two gauze-covered partially-demineralized human enamel specimens for 14 days and brushed 2×/day with their assigned dentifrice: Study 1: sodium fluoride (NaF)/Carb/silica, NaF/silica, NaF + monofluorophosphate (MFP)/chalk; Study 2: NaF/Carb/silica, NaF + MFP/dical, amine fluoride (AmF)/silica; Study 3: NaF/Carb/silica, NaF + stannous fluoride (SnF2)/silica/hexametaphosphate (HMP). All studies included Placebo (0 ppm F) and/or dose-response controls (675 ppm F as NaF [675F-NaF]) ±Carb. Specimens were evaluated for percentage surface microhardness recovery (SMHR) and enamel fluoride uptake (EFU). Results All 1400–1450 ppm F dentifrices except NaF + SnF2/silica/HMP provided significantly greater lesion remineralization than Placebo (p < 0.0001): differences in SMHR ranged from 17.46% (NaF + MFP/dical) to 26.66% (AmF/silica). For EFU (back-transformed log EFU), all 1400–1450 ppm F dentifrices gave significant fluoride uptake compared to Placebo (p < 0.0001): increases in EFU ranged from 4.95 μg F/cm2 (NaF + SnF2/silica/HMP) to 16.32 μg F/cm2 (NaF/carb/silica). Dentifrices containing NaF or AmF as sole fluoride source provided the greatest remineralization and fluoridation; Carb addition did not alter fluoride efficacy; some excipients appeared to interfere with the cariostatic action of fluoride. Treatments were generally well-tolerated with ≤4 treatment-related adverse events per study. Conclusion Commercially available fluoride dentifrices varied greatly in their ability to remineralize and fluoridate early caries lesions. Clinical significance Fluoride dentifrices are the most impactful anticaries modality worldwide. While clinical caries trials have not consistently shown the superiority of one formulation over another, these findings using a sensitive in situ caries model indicated that dentifrices containing NaF or AmF as the sole fluoride source provided the greatest remineralization and fluoridation benefits

Identification of the OGLE-2003-BLG-235/MOA-2003-BLG-53 Planetary Host Star

We present the results of HST observations of the host star for the first definitive extrasolar planet detected by microlensing. The light curve model for this event predicts that the lens star should be separated from the source star by ~6mas at the time of the HST images. If the lens star is a late G, K or early M dwarf, then it will be visible in the HST images as an additional source of light that is blended with the source image. Unless the lens and source have exactly the same colors, its presence will also be revealed by a systematic shift between centroids of the source plus lens in different filter bands. The HST data indicates both of these effects: the HST source that matches the position of the source star is 0.21 magnitudes brighter in the ACS/HRC-F814W filter than the microlensing model predicts, and there is an offset of ~0.7mas between the centroid of this source in the F814W and F435W filter bands. We conclude the planetary host star has been detected in these HST images, and this identification of the lens star enables a complete solution of the lens system. The lens parameters are determined with a Bayesian analysis, averaging over uncertainties in the measured parameters, interstellar extinction, and allowing for the possibility of a binary companion to the source star. This yields a stellar mass of M_* = 0.63(+0.07/-0.09) M_solar and a planet mass of M_p = 2.6 (+0.8/-0.6) M_Jup at an orbital separation of 4.3 (+2.5/-0.8) AU. Thus, the lens system resembles our own Solar System, with a planet of ~3 Jupiter-masses in a Jupiter-like orbit around a star of two-thirds of a Solar mass. These conclusions can be tested with future HST images, which should reveal a broadening of the blended source-plus-lens point spread function due to the relative lens-source proper motion.Comment: 11 pages, with 3 figures. to appear in ApJ Lett (Aug 20 issue

Community understanding of tsunami risk and warnings in Australia

The development of the Australian Tsunami Warning System (ATWS) was in recognition of the fact that the Australian coastline faces some 8000 km of active tectonic plate boundary capable of generating a tsunami that could reach Australia in two to four hours. The work reported in this paper complements an earlier questionnaire study (Paton, Frandsen &amp; Johnston 2010) with detailed interview data to inform understanding of respondents' awareness of tsunami risk and their willingness (or lack of) to respond to a rare but possible natural hazard. A belief that no tsunami events had occurred in Australia (at least since colonial times) and that major causes (e.g. seismic and volcanic) were absent, supported the view of participants that tsunami is a non-existent or a very lowprobability hazard for Australia. This view was reinforced by the lack of discussion of tsunami by government or in the media. The ensuing sense of 'risk rejection' resulted in respondents believing that no resources or effort should be directed to tsunami risk reduction. The data raises the possibility that the ATWS may not be fully effective unless action is taken to increase tsunami risk acceptance and readiness. Recommendations for doing so draw on participant discussions of how to localise risk reduction activities. Their suggestions for increasing tsunami readiness in coastal communities included integrating it with community-based, localised discussions around frequent flash floods, coastal storms, bushfires and climate change hazards. These concepts are discussed, as well as the use of local volunteer resources to develop preparedness activities.</p

Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle

Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization. Our objectives were to measure insulin-sensitive glucose metabolism in neonatal lambs with IUGR and to determine whether daily treatment with ADRβ2 agonist and ADRβ1/β3 antagonists for 1 month normalizes their glucose metabolism. Growth, glucose-stimulated insulin secretion (GSIS) and glucose utilization rates (GURs) were measured in control lambs, IUGR lambs and IUGR lambs treated with adrenergic receptor modifiers: clenbuterol atenolol and SR59230A (IUGR-AR). In IUGR lambs, islet insulin content and GSIS were less than in controls; however, insulin sensitivity and whole-bodyGUR were not different from controls.Of importance, ADRβ2 stimulation with β1/β3 inhibition increases both insulin sensitivity and whole-body glucose utilization in IUGR lambs. In IUGR and IUGR-AR lambs, hindlimb GURs were greater but fractional glucose oxidation rates and ex vivo skeletal muscle glucose oxidation rates were lower than controls. Glucose transporter 4 (GLUT4) was lower in IUGR and IUGR-AR skeletal muscle than in controls but GLUT1 was greater in IUGR-AR. ADRβ2, insulin receptor, glycogen content and citrate synthase activity were similar among groups. In IUGR and IUGR-AR lambs heart rates were greater, which was independent of cardiac ADRβ1 activation. We conclude that targeted ADRβ2 stimulation improved whole-body insulin sensitivity but minimally affected defects in GSIS and skeletal muscle glucose oxidation. We show that risk factors for developing diabetes are independent of postnatal catch-up growth in IUGR lambs as early as 1 month of age and are inherent to the islets and myocytes

MitoNeoD:a mitochondria-targeted superoxide probe

Mitochondrial superoxide (O2⋅−) underlies much oxidative damage and redox signaling. Fluorescent probes can detect O2⋅−, but are of limited applicability in vivo, while in cells their usefulness is constrained by side reactions and DNA intercalation. To overcome these limitations, we developed a dual-purpose mitochondrial O2⋅− probe, MitoNeoD, which can assess O2⋅− changes in vivo by mass spectrometry and in vitro by fluorescence. MitoNeoD comprises a O2⋅−-sensitive reduced phenanthridinium moiety modified to prevent DNA intercalation, as well as a carbon-deuterium bond to enhance its selectivity for O2⋅− over non-specific oxidation, and a triphenylphosphonium lipophilic cation moiety leading to the rapid accumulation within mitochondria. We demonstrated that MitoNeoD was a versatile and robust probe to assess changes in mitochondrial O2⋅− from isolated mitochondria to animal models, thus offering a way to examine the many roles of mitochondrial O2⋅−production in health and disease

Transmission of Salmonella enteritidis after endoscopic retrograde cholangiopancreatography because of inadequate endoscope decontamination

We report a historic nosocomial outbreak of Salmonella enteritidis affecting 4 inpatients who underwent endoscopic retrograde cholangiopancreatography. The cause was attributed to inadequate decontamination of an on-loan endoscope used over a weekend. This report highlights the risks of using on-loan endoscopes, particularly regarding their commissioning and adherence to disinfection protocols. In an era of increasing antibiotic resistance, transmission of Enterobacteriaceae by endoscopes remains a significant concern